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NSuite is a framework for maintaining and running benchmarks and validation tests for multi-compartment neural network simulations on HPC systems. NSuite automates the process of building simulation engines, and running benchmarks and validation tests. NSuite is specifically designed to allow easy deployment on HPC systems in testing workflows, such as benchmark-driven development or continuous integration.

There are three motivations for the development of NSuite:

  1. The need for a definitive resource for comparing performance and correctness of simulation engines on HPC systems.
  2. The need to verify the performance and correctness of individual simulation engines as they change over time.
  3. The need to test that changes to an HPC system do not cause performance or correctness regressions in simulation engines.

    The framework currently supports the simulation engines Arbor, NEURON, and CoreNeuron, while allowing other simulation engines to be added.

Other software

All software


A SciUnit library for data-driven testing of basal ganglia models. Employed for testing via the HBP Validation Framework. This test shall take as input a BluePyOpt optimized output file, containing a hall_of_fame.json file specifying a collection of parameter sets. The validation test would then evaluate the model for all (or specified) parameter sets against various eFEL features.

Validation and inference


The EBRAINS Collaboratory offers researchers and developers a secure environment to work with others. You control the level of collaboration by sharing your projects with specific users, teams or all of the Internet. Many researchers are sharing their work already; several services, tools, datasets, and other resources are publicly available, and many more are available for registered users.

DataBrain atlasesModelling and simulationValidation and inference

Connectivity-based Psychometric Prediction Framework

To better understand the relationships between interindividual variability in brain regions’ connectivity and behavioural phenotypes, we are developing a connectivity-based psychometric prediction framework (CBPP). Preliminary to the development of this region-wise machine learning approach, we performed an extensive assessment of the general connectivity-based psychometric prediction (CBPP) framework based on whole-brain connectivity information. Because a systematic evaluation of different parameters was lacking from previous literature, we evaluated several approaches pertaining to the different steps of a CBPP study. We hence tested 72 different approach combinations (3 types of preprocessing x 4 parcellation granularity x 2 connectivity methods x 3 regression methods = 72 combinations) in a cohort of over 900 healthy adults across 98 psychometric variables. Overall, our extensive evaluation combined to an innovative region-wise machine learning approach offer a framework that optimises both, prediction performance and neurobiological validity (and hence interpretability) for studying brain-behaviour relationships.

Validation and inference

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